IndraLab

Kinase Enrichment Analysis

This application performs kinase over-representation analysis to identify kinases that are statistically enriched for a set of phosphosites based on assembled kinase-substrate relationships.
The analysis uses phosphorylation data from the INDRA knowledge graph to identify upstream kinases that are likely responsible for the phosphorylation patterns in your dataset.

The corresponding REST API endpoint for this analysis is /api/kinase_analysis. You can find it on the API Docs under the section 'Analysis Queries'.

Paste your list of phosphosites in the format 'GENE-SITE' (e.g., 'MAPK1-T202', 'AKT1-S473') or click here to use an example list.
Enter background phosphosites. If not provided, all phosphosites in the database will be used.
The minimum number of evidences for a relationship to be included.
The minimum belief score for a relationship to be included.
The alpha is the threshold for significance in the Fisher's exact test with which multiple hypothesis testing correction will be executed.