Kinase Enrichment Analysis

This application performs kinase over-representation analysis to identify kinases that are statistically enriched for a set of phosphosites based on assembled kinase-substrate relationships.
The analysis uses phosphorylation data from the INDRA knowledge graph to identify upstream kinases that are likely responsible for the phosphorylation patterns in your dataset.

The corresponding REST API endpoint for this analysis is /api/kinase_analysis. You can find it on the API Docs under the section 'Analysis Queries'.

Minimum Evidence Count The minimum number of evidences, if using INDRA path-based analysis.

Minimum Belief The minimum belief score, if using INDRA path-based analysis.

Keep insignificant results (leads to long results lists)

Alpha The alpha is the threshold for significance in the Fisher's exact test with which multiple hypothesis testing correction will be executed.

Multiple Hypothesis Test Correction

Family-wise Correction with Benjamini/Hochberg

Bonferroni (one-step correction)

Sidak (one-step correction)

Holm-Sidak (step down method using Sidak adjustments)

Holm (step-down method using Bonferroni adjustments)

Two step Benjamini and Hochberg procedure

Two step estimation method of Benjamini, Krieger, and Yekutieli

Phosphosites Paste your list of phosphosites in the format 'GENE-SITE' (e.g., 'MAPK1-T202', 'AKT1-S473') or click here to use an example list.

Background Phosphosites (Optional) Enter background phosphosites. If not provided, all phosphosites in the database will be used.

IndraLab

Kinase Enrichment Analysis