IndraLab

Signed Gene Set Analysis

This application performs signed gene set enrichment analysis using INDRA CoGEx and the Reverse Causal Reasoning algorithm.
See: Catlett, N. L., et al. (2013): Reverse causal reasoning: applying qualitative causal knowledge to the interpretation of high-throughput data. BMC Bioinformatics, 14 (1), 340.

The corresponding REST API endpoint for this analysis is /api/signed_analysis. You can find it on the API Docs under the section 'Analysis Queries'.

Paste your list of gene symbols, HGNC gene identifiers, or CURIEs here
Paste your list of gene symbols, HGNC gene identifiers, or CURIEs here or click here to use an example list related to prostate cancer.
The minimum number of evidences for a relationship to be included.
The minimum belief score for a relationship to be included.
The alpha is the threshold for significance in the Fisher's exact test with which multiple hypothesis testing correction will be executed.