Metabolite Set Analysis

This application performs metabolite set enrichment analysis using INDRA CoGEx, p-values are calculated using Fisher's exact test with different options available to adjust for multiple hypothesis testing.

The corresponding REST API endpoint for this analysis is /api/metabolite_discrete_analysis. You can find it on the API Docs under the section 'Analysis Queries'.

Metabolites Paste your list of CHEBI identifiers, or CURIEs here or click here to use an example list of metabolites.

Minimum Evidence Count The minimum number of evidences for a relationship to be included.

Minimum Belief The minimum belief score for a relationship to be included.

Alpha The alpha is the threshold for significance in the Fisher's exact test with which multiple hypothesis testing correction will be executed.

Keep insignificant results (leads to long results lists)

Multiple Hypothesis Test Correction

Family-wise Correction with Benjamini/Hochberg

Bonferroni (one-step correction)

Sidak (one-step correction)

Holm-Sidak (step down method using Sidak adjustments)

Holm (step-down method using Bonferroni adjustments)

Two step Benjamini and Hochberg procedure

Two step estimation method of Benjamini, Krieger, and Yekutieli

IndraLab

Metabolite Set Analysis